APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles.
João Pedro Ferrari-Souza,
Firoza Z Lussier,
Douglas T Leffa,
Joseph Therriault,
Cécile Tissot,
Bruna Bellaver,
Pâmela CL Ferreira,
Maura Malpetti,
Yi-Ting Wang,
Guilherme Povala,
Andréa L Benedet,
Nicholas J Ashton,
Mira Chamoun,
Stijn Servaes,
Gleb Bezgin,
Min Su Kang,
Jenna Stevenson,
Nesrine Rahmouni,
Vanessa Pallen,
Nina Margherita Poltronetti,
John T O'Brien,
James B Rowe,
Ann D Cohen,
Oscar L Lopez,
Dana L Tudorascu,
Thomas K Karikari,
William E Klunk,
Victor L Villemagne,
Jean-Paul Soucy,
Serge Gauthier,
Diogo O Souza,
Henrik Zetterberg,
Kaj Blennow,
Eduardo R Zimmer,
Pedro Rosa-Neto,
Tharick A Pascoal
Apr 17, 2023
Animal studies suggest that the apolipoprotein E ε4 (APOEε4) allele is a culprit of early microglial activation in Alzheimer's disease (AD). Here, we tested the association between APOEε4 status and microglial activation in...